Daily Archives: March 8, 2014

Nrf2 – Week 22

Specialized Knowledge

In the Franklin Makeover this week, my character awareness is Specialized Knowledge which just happens to correspond with our reading in the Master Keys Lesson 22.   This may get very dry scientifically and technically but I have been studying about how unique are our cells, and more precisely, the importance of Nrf2.

22.15  Every cell in your body is intelligent and will respond to your direction.  The cells are all ImageProxy.mvccreators and will create the exact pattern which you give them.

While the Master Keys goes on to explain that every element of the human body is the result of a rate of vibration which is controlled by mental action…high and low…positive and negative; and  as these millions of repair cells are all intelligent and respond to our thought, so long as we do not interfere with thoughts of fear, doubt, and anxiety, the result is perfect.  


I’m going to digress a little into study of a protein –Nrf2– located in every cell of our body.  It is very important to its function and viability of our organs.

Science shows that Nrf2 activation is the cutting edge medical science topic in the world right now, and big Pharmaceutical companies and other natural supplements manufacturers are scrambling to catch up! 

Every second of every day of our lives, our cells are bombarded by toxins that are produced when we consume food, absorb chemicals from our personal care products, and take in oxygen.  These toxins, known as oxidants or free radicals, wreak havoc on all the components of our cells.

Dr. Joe McCord, world renowned scientist and pioneer in free radical biology, explains  that our bodies were designed to eliminate free radicals by the activity of a specific group of enzymes produced inside our cells, called antioxidant enzymes, which include Superoxide Dismutase (SOD), Catalase, and Glutathione. 

Dr. McCord was awarded the Elliot Cressan Medal from the Franklin Institute for the discovery of SOD putting him in the same company with Pierre and Marie Curie, Alexander Graham Bell, Orville Wright and Henry Ford.

What is Oxidative Stress?

Oxidative stress is damage to the cells of your body.  MUTATIONS:  Changes NORMAL cells to ABNORMAL ones.  It happens  because of the overabundance of toxins in our food, water, air, personal care products, cleaning products, EMF’s from our cell phones, and the free radicals in our bodies are raging out of control because our bodies simply can no longer keep up – they’ve worked themselves right into exhaustion! 

When free radicals are more rampant than antioxidant enzymes, then those free radicals bounce around inside the body, causing damage to all of our cells.  This cellular damage is called oxidative stress. The problem?  Oxidative stress leads to malfunction, disease, and accelerated aging.  Yep, that’s a problem!  And EVERYBODY has it!

Critical to the fight against oxidative stress is the transcription factor (a protein messenger) called nuclear factor (erythroid-derived 2)-like 2, or Nrf2, found in every cell of the body.

Nrf2 is referred to as the “master regulator” of the antioxidant response, regulating the expression of hundreds of genes, including the familiar antioxidant enzymes SOD, Catalase, and Glutathione, as well as large numbers of genes that control other ‘survival’ processes such as immune system and inflammatory responses, tissue remodeling and fibrosis, carcinogenesis and metastasis, and even cognitive dysfunction and addictive behavior.

Thus, the lack of regulation of Nrf2-regulated genes (because Nrf2 is inactive due to an overwhelmed, exhausted body) provides a logical explanation for the connections between oxidative stress and perhaps 200 human illnesses and diseases.

Well, now that I have completely overwhelmed everyone with Specialized Knowledge in the cell realm, let’s abbreviate the talking points.

  • Nrf2 regulates the body’s survival genes and processes. 
  • If Nrf2 isn’t active, then survival genes and processes aren’t regulated. 
  • If survival genes and processes aren’t regulated, then things like oxidative stress, out-of-control inflammation, lacking or over-active immune system responses, out-of-control fibrotic responses, the creation and spread of cancer cells, brain/neurological dysfunction, and addictive behavior, are all likely results.

Currently, there are over 3,000 published medical studies on Nrf2, from medical universities all over the world, all of which you can see at www.PubMed.gov, researching topics such as Nrf2 and cancer, Nrf2 and heart disease, Nrf2 and diabetes, Nrf2 and oxidative stress, Nrf2 and arthritis, Nrf2 and Parkinson’s disease, Nrf2 and MS…just search the disease of your choice and see how it is related with Nrf2.

The Solution

So what is the solution to Oxidative Stress?  Dr. Joe McChord developed a supplement that activates our own cellular Nrf2, instructing the cell to make more protective, survival-related enzymes. While direct antioxidants ( Vitamin 3, Vitamin E, Blueberries, Acai Berries) eliminates free radicals 1:1, this supplement increases the enzymes in your body that can eliminate 1,000,000 free radicals per second, every second.  Some of these enzymes that get turned on in our body—for example Glutathione, Catalase, and SOD—fight ‘oxidative stress.’

This supplement is the only product ‘Clinically Proven’ to reduce oxidative stress by an average of 40% in everyone within the first 30 days of daily use.  (free radica biol med. 2006 Jan.15; 40 (2) 34 1-7): University of Colorado.  It is protected by 7 patents to keep its integrity.

The name of this supplement is Protandim.  It also has been reviewed and validated by investigators in the laboratories of highly respected universities and institutions of research and additional studies are under way around the world to test its efficacy and capabilities.

Master Key 22.27  There can be no doubt that few patients are aware how much they can do for themselves.  What the patient can do for himself, the forces he can set in motion are as yet unknown.  We are inclined to believe that they are far greater than most imagine…

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